Refractory medicine
WebRefractory and super-refractory status epilepticus (SE) are serious illnesses with a high risk of morbidity and even fatality. In the setting of refractory generalized convulsive SE (GCSE), there is ample justification to use continuous infusions of highly sedating medications-usually midazolam, pentobarbital, or propofol. WebOct 5, 2024 · Ethan Deckert, MD, examines treatment options for refractory ventricular fibrillation. Tones ring out and dispatch announces a 9-Echo call in your district: an approximately 35-year-old male was ...
Refractory medicine
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WebJan 31, 2024 · The word “refractory” in general use means stubborn or intractable, and in medicine it is specifically applied to disease that does not respond to treatment. Refractory cancer refers to cancer that may be resistant at the beginning of treatment, or becomes … Web5 hours ago · Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment landscape of relapsed/refractory multiple myeloma (RRMM), leading to unprecedented responses in this patient population. Idecabtagene vicleucel (ide-cel) has been recently approved for treatment of triple-class exposed RRMM. We report real-life …
WebApr 14, 2024 · A Clinical Safety and Efficacy Study on Oncolytic Virus Injection (R130) for the Treatment of Relapsed/Refractory Cervical and Endometrial Cancer: Actual Study Start … WebJan 7, 2024 · Corticosteroids (at low doses) should be reserved for those who have failed multiple attempts at therapy with an NSAID plus colchicine. Anti-interleukin 1 therapy (e.g., anakinra and rilonacept) has been shown to be beneficial in patients with refractory, corticosteroid-dependent disease.
WebKeywords: multiple myeloma, refractory/relapsed, treatment regimens, efficacy, network meta-analysis. Introduction. Since the early 2000s, the introduction of newly developed agents has dramatically improved the outcome of patients with multiple myeloma. However, the refractory/relapsed multiple myeloma (RRMM) remains a big challenge, due to ... WebApr 15, 2024 · Potential treatment-emergent adverse events were grade 1 increased stoma output and fatigue and grade 2 vomiting. Best response observed was stable disease in three solid-tumor patients (11.1%). The pharmacokinetics of PRL3-zumab were dose proportional, consistent with an IgG type monoclonal antibody. ... refractory solid tumors …
Web5 hours ago · Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment landscape of relapsed/refractory multiple myeloma (RRMM), leading to …
WebNov 11, 2024 · Refractory hypoxemia can occur in a small subset of patients with acute respiratory failure and mechanical ventilation. Acute respiratory distress syndrome (ARDS) is the most common cause of refractory hypoxemia in patients with acute respiratory failure. Unmanageable refractory hypoxemia remains a most feared condition encountered by … tle lebfrommWebDrug-resistant epilepsy occurs when a person has failed to become (and stay) seizure free with adequate trials of two seizure medications (called ASMs). These seizure medications … tle itWebPoor compliance with medicine or factors such as severe sleep deprivation or alcohol consumption may limit how well medication works. Properly diagnosed seizures sometimes do not respond even to the best medical treatment. Not all uncontrolled seizures are considered refractory or drug resistant. For example: tle knoWebNov 21, 2024 · In October 2024, the European Medicines Agency validated for review a Marketing Authorization Application (MAA) for epcoritamab for the treatment of patients … tle mathstle locality rateWebJun 17, 2024 · A second point of emphasis is the continued role of BZDs for pharmacologic treatment of moderate to severe anxiety, particularly panic disorder and more refractory generalized anxiety disorder. Effective clinicians should be comfortable prescribing these medications among patients for whom they are appropriate and in situations that … tle major subjectsWebSep 9, 2024 · The word “refractory” in general use means stubborn or intractable, and in medicine it is specifically applied to disease that does not respond to treatment. … tle increased