Cellular response to fluid shear stress
WebFeb 15, 2010 · A three-dimensional transient model of cellular growth based on the Navier–Stokes equations that simulates the body fluid flow and stimulation of bone precursor cellular growth, attachment, and proliferation as a function of local flow shear stress is presented. 23 PDF View 2 excerpts, cites background WebWith application of fluid shear (3 dyn/cm 2 ), the HUVEC-CTRL cells formed stress fibres that aligned with the direction of flow regardless of VEGF stimulation (Fig. 3E).
Cellular response to fluid shear stress
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WebJun 6, 2014 · Ando J., Yamamoto K. Vascular mechanobiology: endothelial cell responses to fluid shear stress. Circ. J. 2009; 73:1983–1992. [Google Scholar] Barakat A.I. Responsiveness of vascular endothelium to shear stress: potential role of ion channels and cellular cytoskeleton (review) Int. J. Mol. Med. 1999; 4:323–332. [Google Scholar] WebMechanical environment was illustrated to play significant roles in regulating cell biological activities and maintaining homeostasis. 32 Moreover, aberrant mechanical force may …
WebSignificance A great deal of research has investigated the biochemical factors that regulate angiogenic sprouting, but less is known about the role of fluid shear stress. Some … WebMar 30, 2024 · Shear stress is a fundamental determinant of vascular homeostasis, regulating vascular remodelling, cardiac development and atherogenesis, but the mechanisms of transduction are poorly understood. Previous work showed that the conversion of integrins to a high-affinity state mediates a subset of shear responses, …
WebApr 11, 2024 · Endothelial cells (ECs) continuously sense and adapt to changes in shear stress generated by blood flow. Here, we show that activation of the mechanosensitive channel Piezo1 by defined shear forces induces Ca 2+ entry into the endoplasmic … WebJan 1, 2013 · This paper provides an economical and high efficient kind of microfluidic chip device which can investigate cells' response under different magnitude of fluid shear stress (FSS) at the same time.
WebSep 1, 2001 · The ability of arterial endothelial cells to sense and respond to changes in fluid mechanical shear stress is essential for vasoregulation and for vascular wall remodeling and may play a role in the development and localization of …
WebCells regularly experience fluid flow in natural systems. However, most experimental systems rely on batch cell culture and fail to consider the effect of flow-driven dynamics on cell physiology. ... High shear rates replenish H2O2, abolish gradients, and generate a stress response. Combining mathematical simulations and biophysical experiments ... crumlin village pharmacybuild your own rack serverWebAtherosclerosis is an inflammatory disease initiated by endothelial activation, in which lipoprotein, cholesterol, extracellular matrix, and various types of immune and non … crumlishWebFluid shear stress appears to have a positive effect on the synthesis of glucosaminoglycans in chondrocytes in culture, although hydrostatic pressure appears to … build your own radiatorWebMay 13, 1997 · Removal of the fluid shear stress in turn led to the return of pseudopod projection and cell spreading. When steady shear stress was prolonged over several … build your own rack mount serverWebSep 1, 2001 · Endothelial cells are normally exposed constantly to mechanical forces that significantly influence their phenotype. This symposium presented recent information … build your own radionics machineWebJan 7, 2000 · There is now evidence that all cells in the circulation respond to physiological shear stress, including endothelial cells, 1 erythrocytes, 2 platelets, 3 and leukocytes. 4 Human leukocytes (neutrophils, monocytes, and lymphocytes) respond to fluid shear stress by retraction of pseudopods (lamellipodia, filopodia, and other forms) and … crumlish obituary